SpeedGrader/Crocodoc comments do not have a "save" button!!
(1) Each comment is saved when you finish with it and ...
(2) create a new one. The last comment will only be saved...
(3) if you click just outside of the last comment in the Crocodoc screen.
(4) Once you have completed your comments, you can navigate to the Canvas submit screen to enter the student's grade, or enter further comments in the "Add a Comment" box (text or media),or attach a file. The Submit Comment button in the lower right is for the "Add a Comment" not for Crocodoc.